TABLE 1. TABLE 1A Animal Studies of CRF and Intestinal Metabolism and Transport.

INTESTINE	Protein	Activity	Effect on F
TRANSPORTERS
Pgp	↓65% Naud [83]	↓30% Naud [83]	↑
ABCB1	↔ Veau [84]	↓41% Veau [84]
MRP2	↓60% Naud [83]	↓25% Naud et al.	↑
ABCC2
MRP3	↓35% Naud [83]	NA	↓
Oatp2	↔ Naud [83]	↔	↔
SLCO
ENZYMES
CYP1A1	↓40% Leblond [48]	↓25% Leblond [48]	↑
CYP2C11	↔ Leblond [48]	NA	↔
CYP3A2	↓70% Leblond [48]	↓25% Leblond [48]	↑
TABLE 1B Animal Studies of CRF and Hepatic CYP Metabolism and Transport
LIVER	Protein	Activity	Effect
TRANSPORTERS
Pgp	↑25% Naud [80]	↑45% [80]	↑ Biliary Excretion
ABCB1	↔ Laouari [79]		?
MRP2	↔ Naud [80]	NA	NA
ABCC2	↑ 70-200% Laouari [79]
Oatp2	↓40% Naud [80]	NA	↓ Biliary Excretion
SLCO			↓ metabolic CL
ENZYMES
CYP1A1	↔	↔ Leblond [40,41]	↔ Hepatic CL
CYP2C11	↓40-45% Leblond [40] Uchida [39]	↓35% Leblond [40,41] Uchida [39]	↓ CL
CYP2D	↔ Leblond [41]	↔ Leblond [41]	↔ CL
CYP3A1	↓75-85% Leblond [40,41]	↓35% Leblond [40,41]	↓ CL
CYP3A2	↓45-65% Leblond [40,41] Uchida [39]	↓35-50% Leblond [40,41]	↓ CL
Nat 1	↓33% Simard [77]	↓45% Simard [77]	↓ CL
Nat 2	↓50% Simard [77]	↓50% Simard [77]	↓ CL

? = limited data