Figure 5.
Cardiac hypertrophy in SUR2 null mice. A. Representative photomicrographs of hemotoxylin and eosin and Masson trichrome stained sections from control and SUR2 null hearts. Despite significant increases in heart size, SUR2 null hearts exhibited no fibrosis, cardiomyocyte disarray or other structural defects. (Scale bar = 0.5 mm) B. Hearts from SUR2 null mice are significantly larger than matched control hearts as measured by ventricular weight or relative heart size (ventricular weight/body weight, gm/gm). * p<0.05, n=16 and n=20 for control and SUR2 null cohorts, respectively. C. Average body weight of the control and SUR2 null cohorts were not significantly different.