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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: Aging Cell. 2007 Feb;6(1):111–119. doi: 10.1111/j.1474-9726.2006.00266.x

Fig. 2.

Fig. 2

Lifespan extension by inhibiting ifg-1 and rsks-1 and their interaction with other longevity genes. (a) Mean lifespan was 16.4 days (n = 100) for N2 on control RNAi; 20 days (n = 116) for rsks-1(RNAi); and 22.3 days (n = 164) for ifg-1(RNAi) (P < 0.0001). (b) Mean lifespan was 19.2 days (n = 83) for N2 on control RNAi; 29.8 days (n = 83) for N2 on 1: 1 ifg-1(RNAi) and control RNAi; 21.2 days (n = 87) for 1: 1 let-363(RNAi) and control RNAi; and 32 days (n = 59) for N2 on 1: 1 ifg-1(RNAi) and let-363(RNAi) (P < 0.0001). (c) Mean lifespan was 19.2 days (n = 83) for N2 on control RNAi; 21 days (n = 78) for rsks-1(ok1255) on control RNAi; 30.6 days (n = 67) for rsks-1(ok1255) on 1: 1 ifg-1(RNAi) and control RNAi (P < 0.0001); and 16.1 days (n = 67) for 1: 1 let-363 (RNAi) and control RNAi. (d) daf-2(e1370) on control RNAi, rsks-1(RNAi), and ifg-1(RNAi). Mean lifespan was 30.8 days (n = 115) for daf-2(e1370) on control RNAi; 38.1 days (n = 119) for rsks-1(RNAi); and 52.3 days (n = 55) for ifg-1(RNAi) (P < 0.0001). (e) Mean lifespan was 12 days (n = 144) for daf-16(mu86) on control RNAi; 13.7 days (n = 136) for rsks-1(RNAi); and 15.2 days (n = 138) for ifg-1(RNAi) (P < 0.0001). (f) Mean lifespan was 19.6 days (n = 128) for clk-1(e2519) on control RNAi; 22.1 days (n = 95) for rsks-1(RNAi); and 24.1 days (n = 127) for ifg-1(RNAi) (P < 0.0001). (g) Mean lifespan was 19.5 days (n = 138) for eat-2(ad456) on control RNAi; 21.7 days (n = 133) for rsks-1(RNAi); and 30.1 days (n = 153) for ifg-1(RNAi) (P < 0.0001). (h) Mean lifespan was 15.2 days (n = 95) for sir-2.1(ok424) on control RNAi; 20.2 days (n = 105) for rsks-1(RNAi); and 29.3 days (n = 75) for ifg-1(RNAi) (P < 0.0001). Similar results were obtained in at least two separate experiments for each panel.