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The simulated concentrations of active CaN and CaMK (colour coding matches Figure 1). The enzyme activities at pacing steady-state are shown in relation to the maximum pacing-induced value (at 4 Hz). The divergent pacing dependence of calcineurin (CaN) and Ca2+/calmodulin-dependent protein kinase II (CaMK) is demonstrated even more clearly in the inset, which shows the enzyme activities scaled to the maximum calcium-induced value.
