Table 1.
Comparison of the AP properties of the model and experimental data
Magnitude | Simulated value | Experimental value |
Quiescent [Na+]i (mM) | 13.6 | 16.4 ± 0.7 [66]; 15.6 ± 0.7 [66]; 12.5 ± 1.8 [67] |
Quiescent [K+]i (mM) | 143.0 | ~140 [81] |
Quiescent EK (mV) | -84.1 | ~-80 [81] |
Quiescent V (mV) | -79.0 | ~EK [81] |
AP amplitude (mV) at 1 Hz | 110.6 | 106 ± 11 [20]; 118 [68] |
AP 50% duration (ms) at 1 Hz | 3.25 | 4.5 ± 0.3 [69]; 2.6 ± 0.1 [59]; 1.6 ± 0.2 [20] |
dV/dtmax (V/s) at 1 Hz | 148.4 | 161 ± 44 (neonatal cell culture) [70] 193.25 ± 13.94 (rat) [71]; 133.8 ± 9.2 (42 days old) [58] |