Table 3.

Modified parameter values of the previously published model components

Symbol	Description	Criteria for Modification	Value
GNa	Maximum conductance of fast Na+ current (mS/μF)	Increasing dV/dtmax of Vm	14.5
	Maximum Ca2+ transport rate of PMCA (pA/pF)	Adjusting Ca2+ circulation fraction	0.05
GCab	Conductance of background Ca2+ current (mS/μF)	Adjusting SR calcium content	3.4 × 10-4
	Maximum conductance of NKA (pA/pF)	Matching to recent data of ref. [67]	1.4
Km, Nai	Half maximal [Na+]i sensitive activation (mM)	(same as above)	18.6
nNKA	Exponent of NKA Hill equation	(same as above)	3.2
	Ca2+ on-rate for troponin high-affinity sites (μM-1ms-1)	Adapted from ref. [81]	2.37 × 10-3
	Ca2+ off-rate for troponin high-affinity sites (ms-1)	(same as above)	3.2 × 10-5
	Ca2+ on-rate for troponin low-affinity sites (μM-1ms-1)	Lowering of the baseline tension according to data of [21,22]	0.07
SL	Sarcomere length (μm)	Adapted from ref. [22]	2.0
fφ	Scaling factor for the speed of contraction generation'(see eq. A111 in ref.)	Matching the force transient to data of refs. [21,22]	2.3
	Scaling factor for the half maximal transition rate of tropomyosin from permissive to nonpermissive (see eq. A112 and A113 in ref.)	(same as above)	2.8