Table 4.
Initial conditions for the differential parameters
| Parameter | Description | Value (μM) | Refs. |
| CaM | Calmodulin | 6 | [75] |
| CaMK | Basal activity of Ca2+/Calmodulin-dependent Kinase | 10* | [17] |
| total_CaMK | Total amount of Ca2+/Calmodulin-dependent Kinase (buffered) | 10* | [17] |
| CaNAB_Ca2 | Calcineurin with two Ca2+-sites occupied | 1 | [46] |
| I1 | Unphosphorylated form of Protein Phosphatase Inhibitor-1 | 1.8 | [46] |
| I1_x | Phosphorylated form of Protein Phosphatase Inhibitor-1 | 0.001 | [46] |
| PP1_active | Phosphorylated form of Protein Phosphatase 1 | 1.8 | [46] |
| tot_PP1 | Total concentration of Protein Phosphatase 2A | 1.8 | [17] |
| PP2A | Phosphorylated form of Protein Phosphatase 2A | 0.12 | [46] |
| PKA_active | Phosphorylated form of Protein Kinase A (buffered) | 0.014735 | [17] |
| --- | Parameters of the action potential model. | --- | [53] |
| --- | Parameters of the contraction model. | --- | [54] |
* A simplified approach to represent the 10 subunits, when CaMK concentration is 1 μM.