Table 2.
<6% | 6% to <7% | 7% to <8% | 8% to <9% | 9% to <10% | ⩾10% | |
---|---|---|---|---|---|---|
Aggregate end points | ||||||
Complications related to diabetes: | ||||||
Events/person years | 229/9195 | 391/11 432 | 369/8464 | 268/5605 | 159/2542 | 88/1334 |
Unadjusted rate | 24.9 | 34.2 | 43.6 | 47.8 | 62.5 | 65.9 |
Adjusted rate (95% CI) | 35.9 (29.9 to 43.1) | 48.7 (41.3 to 57.3) | 65.5 (55.5 to 77.2) | 74.5 (62.6 to 88.8) | 103.2 (84.2 to 126.5) | 124.9 (97.3 to 160.3) |
Deaths related to diabetes: | ||||||
Events/person years | 56/10 113 | 101/13 143 | 116/10 054 | 84/6595 | 47/3137 | 19/1537 |
Unadjusted rate | 5.5 | 7.7 | 11.5 | 12.7 | 15.0 | 12.4 |
Adjusted rate (95% CI) | 8.9 (6.3 to 12.7) | 12.0 (8.9 to 16.3) | 19.9 (14.8 to 26.7) | 23.5 (17.2 to 32.0) | 29.5 (20.4 to 42.6) | 33.0 (19.8 to 55.1) |
All cause mortality: | ||||||
Events/person years | 112/10 113 | 207/13 143 | 188/10 054 | 123/6595 | 64/3137 | 26/1537 |
Unadjusted rate | 11.1 | 15.8 | 18.7 | 18.7 | 20.4 | 16.9 |
Adjusted rate (95% CI) | 17.0 (13.1 to 22.0) | 23.3 (18.5 to 29.2) | 30.0 (23.8 to 37.7) | 31.8 (24.7 to 40.8) | 37.0 (27.3 to 50.2) | 40.7 (26.5 to 64.5) |
Fatal or non-fatal myocardial infarction: | ||||||
Events/person years | 100/9870 | 163/12 590 | 159/9579 | 101/6331 | 60/3016 | 23/1490 |
Unadjusted rate | 10.1 | 13.0 | 16.6 | 16.0 | 19.9 | 15.4 |
Adjusted rate (95% CI) | 16.0 (12.1 to 21.2) | 20.8 (16.2 to 26.7) | 29.2 (22.8 to 37.4) | 30.0 (22.9 to 39.4) | 39.6 (28.8 to 54.5) | 38.6 (24.4 to 61.0) |
Fatal or non-fatal stroke: | ||||||
Events/person years | 32/9916 | 67/12 869 | 59/9822 | 32/6424 | 13/3062 | 9/1509 |
Unadjusted rate | 3.2 | 5.2 | 6.0 | 5.0 | 4.2 | 6.0 |
Adjusted rate (95% CI) | 4.3 (2.6 to 7.0) | 6.6 (4.4 to 10.1) | 8.3 (5.4 to 12.7) | 7.4 (4.5 to 11.9) | 6.7 (3.5 to 12.7) | 12.0 (5.7 to 25.3) |
Amputation or death from peripheral vascular disease: | ||||||
Events/person years | 3/10 018 | 7/12 993 | 7/9897 | 9/6492 | 15/3061 | 7/1502 |
Unadjusted rate | 0.3 | 0.5 | 0.7 | 1.4 | 4.9 | 4.7 |
Adjusted rate (95% CI) | 1.2 (0.4 to 3.2) | 1.2 (0.5 to 3.1) | 2.6 (1.1 to 5.8) | 4.0 (1.8 to 9.0) | 10.9 (5.0 to 23.7) | 12.2 (4.6 to 32.4) |
Fatal or non-fatal microvascular disease: | ||||||
Events/person years | 38/9814 | 77/12 707 | 86/9438 | 91/6185 | 73/2855 | 47/1432 |
Unadjusted rate | 3.9 | 6.1 | 9.1 | 14.7 | 25.6 | 32.8 |
Adjusted rate (95% CI) | 6.1 (4.1 to 9.0) | 9.3 (6.7 to 12.9) | 14.2 (10.3 to 19.5) | 22.8 (16.7 to 31.3) | 40.4 (28.9 to 56.5) | 57.8 (39.3 to 85.1) |
Single end points | ||||||
Heart failure: | ||||||
Events/person years | 17/9967 | 34/12 928 | 36/9782 | 20/6432 | 10/3062 | 10/1514 |
Unadjusted rate | 1.7 | 2.6 | 3.7 | 3.1 | 3.3 | 6.6 |
Adjusted rate (95% CI) | 2.3 (1.2 to 4.5) | 3.4 (1.9 to 5.8) | 5.0 (2.9 to 8.6) | 4.4 (2.4 to 8.2) | 5.0 (2.3 to 10.6) | 11.9 (5.5 to 25.8) |
Cataract extraction: | ||||||
Events/person years | 35/9841 | 59/12 763 | 49/9692 | 45/6355 | 19/3009 | 19/1495 |
Unadjusted rate | 3.6 | 4.6 | 5.1 | 7.1 | 6.3 | 12.7 |
Adjusted rate (95% CI) | 4.1 (2.5 to 6.5) | 4.5 (3.0 to 6.9) | 4.9 (3.1 to 7.6) | 6.9 (4.4 to 10.8) | 6.6 (3.8 to 11.6) | 14.4 (8.1 to 25.7) |
Person years, events, and unadjusted rates are for all patients.