Table 2.

Univariate and Multivariate Predictors of Locoregional Control and Disease Specific Survival.

	Locoregional Control						Disease Specific Survival
	Univariate			Multivariate‡ (25 events)			Univariate			Multivariate‡ (35 events)
Variable	HR*	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Gross Residual Disease	10.94	4.72–25.3	<.0001	10.84	4.45–26.3	<.0001	4.34	2.12–8.88	<.0001	2.53	1.19–5.35	0.0153
High Risk Histology	3.89	1.76–8.56	0.0008	3.61	1.60–8.17	0.0021	3.32	1.70–6.48	0.0004	2.85	1.45–5.60	0.0023
M Stage (M0, vs. M1)	0.38	0.17–0.83	0.0158				0.30	0.15–0.58	0.0004	0.38	0.19–0.77	0.0071
Histology (PC, vs. FC)†	0.37	0.16–0.86	0.0202				0.44	0.21–0.91	0.0267
Age < 45	0.72	0.25–2.10	0.5442				0.37	0.13–1.07	0.0665
Surgical Margins (+, vs. −)	2.54	1.10–5.91	0.0295				1.34	0.68–2.64	0.4033
Gender (Male, vs. Female)	1.71	0.74–3.96	0.2122				1.42	0.72–2.81	0.3180
Recurrent (No, vs. Yes)	0.64	0.28–1.48	0.2931				0.77	0.39–1.53	0.4580
Number + Nodes§	1.02	0.98–1.06	0.2972				0.97	0.92–1.02	0.1988
Extranodal Spread	1.35	0.56–3.22	0.5060				1.14	0.54–2.38	0.7323
Mediastinal Exploration	0.99	0.44–2.25	0.9893				0.88	0.42–1.84	0.7296
3DRT vs. IMRT	0.68	0.31–1.50	0.3386				1.67	0.76–3.67	0.1983

^*HR-Hazard ratio, determined by Cox Proportional Hazards Model.

^†PC- papillary carcinoma; FC-follicular carcinoma

^§HR per each additional positive nodes

^‡Covariates included in multivariate model if significant on univariate analysis to a Bonferroni corrected p-value ≤ 0.004 (derived from p = 0.05/12 univariate tests)