Table 3.
Univariate and Multivariate Predictors of Overall Survival.
| Overall Survival |
||||||
|---|---|---|---|---|---|---|
| Univariate |
Multivariate‡ (41 events) |
|||||
| Variable | HR | 95% CI | p-value | HR | 95% CI | p-value |
| Gross Residual Disease | 3.54 | 1.77–7.08 | 0.0003 | 2.22 | 1.08–4.59 | 0.0306 |
| High Risk Histology | 3.02 | 1.62–5.61 | 0.0005 | 2.61 | 1.40–4.88 | 0.0027 |
| M Stage (M0, vs. M1) | 0.36 | 0.20–0.68 | 0.0014 | 0.45 | 0.23–0.87 | 0.0176 |
| Histology (PC, vs. FC)† | 0.48 | 0.24–0.97 | 0.0403 | |||
| Age < 45 | 0.30 | 0.11–0.87 | 0.0261 | |||
| Surgical Margins (+, vs. −) | 1.15 | 0.62–2.15 | 0.6582 | |||
| Gender (Male, vs. Female) | 1.60 | 0.84–3.04 | 0.1504 | |||
| Recurrent (No, vs. Yes) | 0.88 | 0.48–1.66 | 0.7101 | |||
| Number + Nodes§ | 0.97 | 0.92–1.01 | 0.1238 | |||
| Extranodal Spread | 1.34 | 0.66–2.76 | 0.4207 | |||
| Mediastinal Exploration | 0.93 | 0.47–1.82 | 0.8227 | |||
| 3DRT vs. IMRT | 1.72 | 0.82–3.60 | 0.1497 | |||
*
HR-Hazard ratio, determined by Cox Proportional Hazards Model.
†
PC- papillary carcinoma; FC-follicular carcinoma
§
HR per each additional positive nodes
‡
Covariates included in multivariate model if significant on univariate analysis to a Bonferroni corrected p-value ≤ 0.004 (derived from p = 0.05/12 univariate tests)