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Hypothetical mechanism for phosphorylation-induced dissociation of Polycomb Repressive Complex (PRC)1 from chromatin. The chromodomain of chromobox homolog (CBX) proteins interacts with H3K27me3. Chromatin dissociation may be the result of ARKS motif methyl-phos switching, by phosphorylation of H3S28 (upper panel). Phosphorylation of conserved residue(s) within the chromodomain of CBX may contribute to chromatin dissociation (lower panel).
