Fig. 4.

Sequence homology between the FPR family members and their tissue distribution. The predicted protein sequences of the three human (h) FPR genes, the eight mouse (m) Fpr genes, and the rabbit (r) FPR1 gene were compared (Boulay et al., 1990a,b; Ye et al., 1993; Gao et al., 1998; Wang et al., 2002). Based on sequence homology, the hFPR1, mFpr1, and rFPR1 are in the same cluster. The mFpr-rs1, mFpr-rs2 (also termed mFpr2), and mFpr-rs8 are in another cluster closely related to hFPR2/ALX and hFPR3. The mFpr-rs3, mFpr-rs4, mFpr-rs6, and mFprrs7 (and, to a lesser extent, mFpr-rs5) are closely related based on their protein sequences (see Table 4 for sequence identity between the gene products). Note that some of these genes are not expressed in neutrophils and monocytes. The tissue expression profiles for mFpr-rs4, mFpr-rs5, and mFpr-rs8 have not been determined. Mo, monocytes; PMN, polymorphnuclear leukocytes; iDC, immature dendritic cells; astro, astrocytes; T, T lymphocytes.