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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Dev Biol. 2009 May 3;331(2):167–175. doi: 10.1016/j.ydbio.2009.04.032

Figure 1. BMPRII deletion by the Mox2-Cre transgene causes perinatal lethality.

Figure 1

(A) Mox2-Cre-mediated recombination was detected by staining for β-galactosidase activity using a ROSA26 reporter allele. At E9.5, gene recombination was detected throughout the embryo (blue staining in the embryo on the right). An embryo without the Mox2-Cre transgene was used as a negative control (embryo on the left). (B) The breeding strategy used to obtain the mutant mice is shown. The three genotypes other than BMPRIIflox/−;Mox2-Cre were used as control mice. (C) Photographs of control and mutant embryos at E16.5 are shown. One of the three mutant mice was alive (left), but other two were found to be dead in utero (middle and right). Scale bars: 1 mm (A) and 5 mm (C).