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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: Dev Biol. 2009 May 3;331(2):167–175. doi: 10.1016/j.ydbio.2009.04.032

Figure 7. Overriding aorta in BMPRIIflox/−;SM22α-Cre and BMPRIIflox/−;Wnt1-Cre mice.

Figure 7

(A–D) Hematoxylin and eosin staining is shown for a control mouse (A) and a BMPRIIflox/−;SM22α-Cre mouse (B) at E14.5, and a control mouse (C) and a BMPRIIflox/−;Wnt1-Cre mouse (D) at P3. The OFT from the left ventricle was severely deviated to the right side of the heart in the BMPRIIflox/−;SM22α-Cre mouse. The aortic valve is located over the right ventricle (B, arrow) in this long axis cross section, whereas the aortic valve in a control mouse is located centrally (A). An overriding aorta with a small VSD (D, arrow) is observed in BMPRIIflox/−;Wnt1-Cre mice, whereas the normal position of the aorta is shown in control mice at P3 (C). AoV: aortic valve. Scale bars: 0.5 mm (A–D).