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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Pediatr Blood Cancer. 2009 Dec;53(6):1120–1123. doi: 10.1002/pbc.22185

Figure 2.

Figure 2

Histopathologic evaluation of vasculitic tissue from the brain. H & E stained sections of autopsy material from the brain of Patient No. 1 demonstrate perivascular lymphohistiocytic infiltrates (A). The lymphocytes are mostly small and round, with benign appearance; scattered cells are medium to large sized (C). Reticulin staining highlights the mononuclear infiltrate within vessel walls and adventitia in a “tree ring” fashion (B). The inflammatory infiltrate is composed of predominantly CD8+ (D), and CD3+ (E) T-lymphocytes. The T-cells show aberrantly decreased or loss of CD5 staining (F).