Table 3.

Observational data analysis of relation between systolic blood pressure exposure and complications of diabetes as estimated by risk reduction for 10 mm Hg reduction in systolic blood pressure, measured at baseline and as updated mean, controlled for age at diagnosis of diabetes, sex, ethnic group, smoking, microalbuminuria, haemoglogin A_1c concentration, high and low density lipoprotein cholesterol, and triglycerides (n=3642) compared with results of clinical trial of tight v less tight blood pressure control policy (n=1148)¹

	No of events	Observational analyses						Clinical trial (less tight v tight policy)1
		Baseline SBP			Updated mean SBP			No of events	Decrease in risk (%)/10 mm Hg difference in SBP (95% CI)	P value
		Decrease in risk (%)/10 mm Hg reduction (95% CI)	P value		Decrease in risk (%)/10 mm Hg reduction (95% CI)	P value
Aggregate end points
Any end point related to diabetes	1255	9 (7 to 12)	<0.0001		12 (9 to 14)	<0.0001		429	24 (8 to 38)	0.0046
Deaths related to diabetes	346	19 (15 to 23)	<0.0001		17 (13 to 21)	<0.0001		144	32 (6 to 51)	0.0019
All cause mortality	597	13 (10 to 17)	<0.0001		12 (9 to 16)	<0.0001		217	18 (−8 to 37)	>0.05
Myocardial infarction	496	13 (9 to 16)	<0.0001		12 (7 to 16)	<0.0001		176	21 (−7 to 41)	>0.05
Stroke	162	13 (7 to 19)	0.0002		19 (14 to 24)	<0.0001		72	44 (11 to 65)	0.013
Peripheral vascular disease*	41	30 (20 to 39)	<0.0001		16 (9 to 23)	<0.0001		16	49 (−37 to 81)	>0.05
Microvascular disease	323	10 (4 to 15)	0.0007		13 (9 to 26)	<0.0001		122	37 (11 to 56)	0.0092
Single end points
Heart failure	104	14 (5 to 21)	0.0016		15 (4 to 19)	<0.0001		45	56 (6 to 80)	0.0043
Cataract extraction	195	7 (0 to 14)	0.043		−3 (−11 to 5)	0.41		42	−34 (40 to −202)	>0.05

SBP=systolic blood pressure. 

^*Lower extremity amputation or fatal peripheral vascular disease.