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. Author manuscript; available in PMC: 2010 Sep 15.
Published in final edited form as: Cancer Res. 2009 Sep 1;69(18):7285–7293. doi: 10.1158/0008-5472.CAN-09-0624

Fig. 2.

Fig. 2

(A) Clonogenic survival following treatment with the APE1 inhibitor CRT0044876 in HCT116 cells at pHe7.4 versus 6.2. The cell survival was dependent on pHe (p<0.001) as well as a dose of CRT0044876 (p<0.001), assessed by ANOVA. (B) 600µM CRT0044876 did not affect cell proliferation of HCT116 cells (upper panel) in monolayer cultures at pHe7.4, whereas cell proliferation was significantly inhibited at the lower pHe values (mean±sem). A similar result was found using U251 cells (lower panel). (C) Clonogenic survival assay following a 48-hour exposure to various doses of H2O2 with or without co-incubation of 600µM CRT0044876 (mean±sem).