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. Author manuscript; available in PMC: 2009 Sep 17.
Published in final edited form as: J Mol Neurosci. 2009 Jan 21;39(1-2):49–58. doi: 10.1007/s12031-008-9174-3

Fig. 2.

Fig. 2

Overexpression of p35 alone, in the absence of leptin or other ligands, was sufficient to induce STAT3 transcriptional activity in HEK293 cells shown by luciferase reporter assays. Both 0.3 µg/ml and 0.4 µg/ml of p35 caused significant increases of STAT3 luciferase activity in comparison with the empty vector control (***: p < 0.005). This contrasts with the lack of effect of Cdk5 or DN-Cdk5 in the absence of ligands. The higher dose of p35 caused a greater increase than the lower dose (+++: p < 0.005 when the 0.3 and 0.4 µg groups were compared).