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. Author manuscript; available in PMC: 2009 Sep 17.
Published in final edited form as: J Mol Neurosci. 2009 Jan 21;39(1-2):49–58. doi: 10.1007/s12031-008-9174-3

Fig. 6.

Fig. 6

Overexpression of Cdk5 (wildtype, WT-Cdk5) in SH-SY5Y cells increased leptin-induced pSTAT3 production at 1, 3, and 6 h, whereas DN-Cdk5 (dominant negative without kinase activity) suppressed it at all time points. This was seen for both Y705 and S727, and did not affect the housekeeping gene β-actin. By contrast, WT-Cdk5 reduced SOCS-3 at 1 and 3 h but increased it at 6 h.