. Author manuscript; available in PMC: 2009 Sep 17.

Published in final edited form as: Pediatr Radiol. 2008 Mar 21;38(5):529–537. doi: 10.1007/s00247-008-0764-6

Table 1.

Selected references of successful in vivo tumor targeting using radionuclides conjugated with the folate-receptor (FR).

Authors	References	FR-targeted radionuclides	Targeted pathology	Targeted species
Mathias et al	J. Nucl. Med. (1998) [16]	¹¹¹In-DTPA- folate	FR-positive KB cells (human nasopharyngeal carcinoma)	mouse
Guo et al	J. Nucl. Med. (1999) [15]	^99mTc-HYNIC- folate	FR-positive 24JK-FBP cells (mouse sarcoma cell)	mouse
Leamon et al	Bioconj. Chem. (2002) [18]	^99mTc-EC20	FR-positive M109 cells (murine lung carcinoma)	mouse
Okarvi et al	Cancer Biother Radiopharm. 2006 [20]	^99mTc-MAG₃- folate	MCF-7 (human breast cancer)	mouse
Bettio et al	J. Nucl. Med. (2006) [13]	¹⁸F-FBA-folate	FR-positive K31 cells (epidermal carcinoma)	mouse