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Intracellular gadolinium or iron-oxide concentration as measured by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in the IGROV-1 cell lysate. The IGROV-1 cells were incubated with FR-targeted contrast agents in the presence or absence of free folate, or with the non-FR-targeted analogs.
| P866 | P866 + folate | P1001 | |
|---|---|---|---|
|
Intracellular gadolinium (nmol Gd / 107 cells) |
0.668 | 0.499 | 0.514 |
| P1048 | P1048 + folate | P904 | |
|
Intracellular iron oxide (nmol Fe / 107 cells) |
18.3 | 12.3 | 13.7 |
