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A and B, Immunostaining for HO-1 expression (arrows) in SAT (Aa and Ab) and VAT (Ac and Ad) from ZDF (Aa and Ac) and ZDF–CoPP (Ab and Ad) rats. B, CoPP treatment increases HO-1 expression in SAT and VAT. C, HO-1 induction resulted in significantly smaller adipocytes in the SAT and VAT of ZDF rats and (D) IOD after immunostaining for the CB-1 receptor in subcutaneous and visceral aortic adipose tissues from ZDF and ZDF–CoPP rats. *P<0.05 control vs diabetic animals; mean±SE; n=40.
