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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Neurobiol Learn Mem. 2009 Jul 24;92(4):581–589. doi: 10.1016/j.nlm.2009.07.007

Figure 5.

Figure 5

Conditioned freezing in rats receiving intra-thalamic infusions of a MEK inhibitor prior to extinction (Experiment 3). (A) Mean percentage of freezing (±SEM) during training that consisted of a pretrial period (Pre) followed by 5 tone-shock presentations. Freezing was measured during the pretrial period and the 1 min intertrial interval. (B) Mean percentage of freezing (±SEM) during the 45 tone-alone extinction session (data are displayed in 15 bins consisting of 3 trials averaged together). Freezing was quantified during the pretrial period and the 30 sec intertrial interval. (C) Mean percentage of freezing (±SEM) during the first 15 minutes of the 45 tone-alone tone test (data are displayed in 5 bins of 3 trials averaged together). Data is shown for rats that were extinguished under U0126 (open squares) or vehicle (filled squares). Data for animals that were not extinguished under vehicle are also shown (open circles).