Table.
Univariate analysis | P value* | Multivariate analysis† | P value* | |
---|---|---|---|---|
Maternal age (years) v <20 | ||||
20-24 | 1.25 (1.19 to 1.32) | <0.0001 | 1.25 (1.17 to 1.34) | <0.0001 |
25-29 | 1.57 (1.39 to 1.77) | 1.57 (1.33 to 1.85) | ||
30-34 | 1.97 (1.65 to 2.35) | 1.98 (1.55 to 2.52) | ||
35-39 | 2.47 (1.95 to 3.13) | 2.48 (1.79 to 3.43) | ||
⩾40 | 3.10 (2.31 to 4.16) | 3.11 (2.07 to 4.66) | ||
Paternal age (years) v <20 | ||||
20-24 | 1.18 (1.12 to 1.24) | <0.0001 | 1.09 (1.03 to 1.16) | 0.003 |
25-29 | 1.39 (1.24 to 1.54) | 1.20 (1.05 to 1.37) | ||
30-34 | 1.63 (1.39 to 1.92) | 1.31 (1.08 to 1.59) | ||
35-39 | 1.92 (1.55 to 2.38) | 1.43 (1.10 to 1.86) | ||
40-45 | 2.27 (1.74 to 2.95) | 1.57 (1.13 to 2.17) | ||
Birth order v 1st born | ||||
2nd | 0.97 (0.92 to 1.03) | 0.37 | 0.85 (0.79 to 0.90) | <0.0001 |
3rd | 0.95 (0.85 to 1.06) | 0.72 (0.64 to 0.80) | ||
4th | 0.93 (0.78 to 1.09) | 0.61 (0.52 to 0.71) | ||
⩾5th | 0.90 (0.72 to 1.13) | 0.52 (0.42 to 0.63) | ||
Male v female | 1.20 (1.08 to 1.33) | 0.0007 | 1.21 (1.08 to 1.35) | <0.0001 |
Significance of overall effect of variable in model.
Relative risk adjusted for three other factors in model.