Table 2.
Markers of Pulmonary Morbidity after Discharge from the NICU
| INO (%) |
Placebo (%) |
OR* (95%CI) |
NNT** (95% CI) |
|
|---|---|---|---|---|
| Wheezing or whistling in the chest | 49.6 | 56.4 | 0.70 (0.48–1.03) | --- |
| Bronchodilator Use | 40.1 | 54.1 | 0.53 (0.36–0.78) | 6.3 (4.0–15.6) |
| Inhaled Steroid Use | 19.8 | 32.4 | 0.50 (0.32–0.77) | 7.5 (4.6, 19.6) |
| Systemic Steroid Use | 11.0 | 17.7 | 0.56 (0.32–0.97) | 14.1 (7.3, 250.0) |
| Diuretic Use | 18.6 | 28.4 | 0.54 (0.34–0.85) | 9.0 (5.2–33.3) |
| Any Home O2 Use | 38.4 | 49.5 | 0.65 (0.44–0.95) | 9.4 (5.0, 76.9) |
| Persistent O2 Use at Time of Follow-Up | 3.0 | 9.4 | 0.30 (0.13–0.73) | 15.9 (9.4–52.6) |
| Any Hospitalization | 46.5 | 50.4 | 0.83 (0.57–1.21) | --- |
| Respiratory Hospitalization | 22.6 | 21.9 | 1.03 (0.65–1.62) | --- |
Odds Ratio
Number needed to treat were calculated by GEE. NNT represents the number of patients that would need to be treated with a therapy in order to improve one patient’s outcome. Respiratory hospitalizations included admissions for wheezing and/or respiratory infection.