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. Author manuscript; available in PMC: 2009 Sep 17.
Published in final edited form as: Neuropsychopharmacology. 2008 Feb 27;33(12):2791–2800. doi: 10.1038/npp.2008.17

Table 4.

Interactive Effects of Single ADORA2A, DRD2, and ANKK1 Polymorphisms Upon Anxiety after 150 mg Caffeine in European-American Participants

ADORA2A DRD2 ANKK1 Significance
Locus Genotype Locus Genotype Locus Genotype R2 P Q
rs5751862 GG, AG, AA rs1079597 AG 0.20 0.007 0.05
GG GG
rs2298383/rs4822492 CC rs1799978 TT 0.23 0.0005 0.01
CT/CG TC
CC rs1079597 GG, AG 0.24 0.0007 0.01
CT/CG AG
CC rs1110976 GG, G− 0.21 0.003 0.02
CT/CG G−
CC rs1800497 CC, CT 0.23 0.0008 0.01

Genotype combinations significantly increase anxiety.