Figure 2.

Decorin inhibited the growth of human prostate cancer cells. (A) PC3, DU145, and LNCaP cells were treated with decorin (0, 0.4, 1, and 2 µM) or biglycan (2 µM, insets), and cell number was measured as absorbance at 490 nm at the indicated times using MTS assay. Data are expressed as fold increases relative to pretreatment (0 time) for each treatment. *P < .05 or **P < .01, compared with control at the same observed time point. (B) PC3, DU145, and LNCaP cells were treated with decorin or biglycan at 0.2, 1, and 2 µM for 24 hours. DNA synthesis was measured by [³H]-thymidine incorporation. Values shown are thymidine incorporation as a percent of control (no decorin) and represent mean ± SD (n = 3). Values with different letters are significantly different (P < .05).