Table 2.
Gene Mutations in KRAS and EGFR in Lung Adenocarcinomas.
Gene and Type of Mutations | No. of Mutations Detected by DS | No. of Mutations Detected by ME-Sequencing |
KRAS | ||
Codon 12 | ||
G34T (G12C) | 8 | 14 |
G35T (G12V) | 3 | 6 |
G35A (G12D) | 3 | 6 |
G34A (G12S) | 0 | 1 |
G35C (G12A) | 1 | 1 |
GG34-35TT (G12F) | 0 | 1 |
Codon 13 | ||
G38T (G13V) | 1 | 1 |
EGFR | ||
Exon 19 | ||
2235–2249del (E746-A750del) | 5 | — |
2236–2250del (E746-A750del) | 3 | — |
2237–2254del (E746_T751del) | 1 | — |
2240–2257del (L747_P753del) | 1 | — |
Exon 21 | ||
T2573G (L858R) | 10 | — |
T2582A (L861Q) | 1 | — |