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. 2009 Jul 14;11(4):R108. doi: 10.1186/ar2763

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Copyright © 2009 Du et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation between GR binding and TNF-α, IL-12 and IFN-γ. Percentage inhibition of (a) TNF-α, (b) IL-12 and (c) IFN-γ cytokine secretion after PBMC incubation in RPMI with PHA plus 10^-6M dexamethasone were correlated to GR binding in (left) CD3⁺and (right) CD14⁺subpopulation in normal controls, SS patients and SR patients. (hollow circle represents normal group, triangle represents SS group, solid circle represents SR group). GR = glucocorticoid receptor; IFN = interferon; IL = interleukin; PBMC = peripheral blood mononuclear cells; SR = steroid-resistant; SS = steroid-sensitive; TNF = tumour necrosis factor.