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. 2009 Aug 17;11(4):R123. doi: 10.1186/ar2789

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Copyright © 2009 Rehnberg et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A representative plot of short-term and long-term changes of the B cell expression of CD38 in combination with CD10/CD24/IgD or CD27 in BM from RA patients receiving rituximab treatment. B cells expressing CD38 were analysed with respect to CD10/CD24, IgD or CD27 expression. Using CD38/IgD, plasmablast (CD38⁺⁺⁺IgD^-), immature and transitional B cells (CD38⁺⁺IgD^+/-), Bm5 (CD38⁺IgD^-), Bm2 (CD38⁺IgD⁺) populations were defined. B cells from a rituximab-naïve patient at (a) day 0, (b) after 3 months, and (c) in a rituximab-treated patient at day 0, is shown for the combination of CD38/CD10/CD24/IgD/CD27.