Table 1.
Demographic and clinical characteristics of 148 patients
| Large cortical/cortical-deep (N = 56) |
Small cortical only (N = 71) |
Deep only (N = 21) |
|
|---|---|---|---|
| Ethnicity | |||
| Caucasian | 37 (66.1 %) | 45 (63.7 %) | 14 (66.7 %) |
| African-American | 7 (12.5 %) | 9 (12.7 %) | 3 (14.3 %) |
| Asian-American | 5 (8.9 %) | 12 (16.9 %) | 3 (14.3 %) |
| Hispanics | 7 (12.5 %) | 5 (7.0 %) | 1 (4.8 %) |
| Site of atherosclerosis | |||
| Ascending/transverse aorta | 7 (12.5 %) | 12 (16.9 %) | 1 (4.8 %) |
| Carotid bifurcation | 27 (48.2 %) | 30 (42.3 %) | 6 (28.6 %) |
| Intracranial | 22 (39.3 %) | 29 (40.8 %) | 14 (66.7 %) |
| Vascular risk factors | |||
| Age | 63.3 ± 14.3 | 72.2 ± 11.51 | 66.4 ± 16.2 |
| Hypertension | 37 (66.1 %) | 58 (81.7 %)2 | 11 (52.4 %) |
| Diabetes | 12 (21.4 %) | 17 (23.9 %) | 5 (23.8 %) |
| Dyslipidemia | 19 (35.2 %) | 40 (56.3 %)2 | 6 (28.6 %) |
| Cigarette smoking | 13 (23.2 %) | 11 (15.5 %) | 5 (23.8 %) |
| Metabolic syndrome | 16 (51.6 %) | 11 (25.0 %)1 | 7 (50.0 %) |
| Previous stroke/TIA | 12 (21.4 %) | 25 (35.2 %) | 6 (28.6 %) |
| Coronary heart disease | 12 (21.4 %) | 17 (23.9 %) | 2 (9.5 %) |
| Peripheral arterial disease | 4 (7.4 %) | 1 (1.4 %) | 1 (5.0 %) |
| Laboratory results | |||
| Glucose | 136.8 ± 52.5 | 123.1 ± 42.8 | 132.8 ± 93.0 |
| Total cholesterol | 182.2 ± 49.7 | 164.0 ± 39.81 | 189.9 ± 54.4 |
| Triglyceride | 135.9 ± 88.3 | 129.7 ± 84.4 | 136.4 ± 85.8 |
| HDL-cholesterol | 47.1 ± 24.0 | 45.5 ± 12.3 | 47.1 ± 12.7 |
| LDL-cholesterol | 110.9 ± 39.9 | 93.8 ± 33.32 | 116.7 ± 44.2 |
| WBC, 109 cells/L | 9.6 ± 2.8 | 9.0 ± 3.5 | 7.2 ± 2.73 |
| C-reactive protein | |||
| Q1–2 (< 0.6 mg/dl) | 13 (39.4 %) | 24 (55.8 %) | 9 (50.0 %) |
| Q3 (0.6–1.84 mg/dl) | 7 (21.2 %) | 11 (25.6 %) | 5 (27.8 %) |
| Q4 (> 1.84 mg/dl) | 13 (39.4 %) | 8 (18.6 %) | 4 (22.2 %) |
| Homocysteine, µM/L | 8.4 ± 3.6 | 9.6 ± 3.6 | 8.4 ± 2.8 |
| NIH stroke score on admission | 14.5 ± 8.44 | 4.5 ± 5.7 | 6.0 ± 4.1 |
| Medications prior to onset | |||
| Statin use | |||
| Non-user | 43 (76.8 %) | 38 (54.5 %)2 | 16 (81.0 %) |
| Low-dose user | 3 (5.4 %) | 9 (12.9 %) | 2 (9.5 %) |
| High-dose user | 10 (17.9 %) | 23 (32.9 %)2 | 2 (9.5 %) |
| Antithrombotic medication | |||
| Antiplatelet agents | 16 (28.6 %) | 29 (40.8 %) | 5 (23.8 %) |
| Anticoagulants | 1 (1.8 %) | 4 (5.6 %) | 2 (9.5 %) |
1
Small cortical only pattern vs. large cortical/cortical-deep pattern, P < 0.05
2
Small cortical only pattern vs. other patterns, P < 0.05
3
Deep only pattern vs. other patterns, P < 0.05
4
Large cortical/cortical-deep pattern vs. other patterns, P < 0.001