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Pharmacokinetic profiling of VU0152099 and VU0152100 in rats. Concentration-time profile of VU0152099 (A) and VU0152100 (B) in brain and plasma of male Sprague-Dawley rats following a 56.6 mg/kg i.p. administration of each compound. Blood and brain tissue were collected at 0.5, 1, 2, and 4 h after injection. Samples were extracted as described under Materials and Methods and analyzed by LC-MS-MS. Each time point represents the mean determination ± S.E.M. of three rats.
