. Author manuscript; available in PMC: 2009 Sep 17.

Published in final edited form as: J Pharmacol Exp Ther. 2008 Sep 4;327(3):941–953. doi: 10.1124/jpet.108.140350

TABLE 2. Pharmacokinetic analysis of VU0152099 and VU0152100.

AUC(0-∞) and t_1/2 values of VU0152099 and VU0152100 in exposure studies in male rats after 56.6 mg/kg i.p. administration. Values represent mean ± S.E.M. (n = 3 rats).

PK Parameter	VU0152099	VU0152100
Mean AUC (0-∞) brain (ng · h/g)	4751.80 ± 666.17	5726.35 ± 694.68
Mean AUC(0-∞) plasma (ng · h/ml)	11928.00 ± 1472.36	6570.35 ± 235.87
AUC brain / AUC plasma	0.39 ± 0.01	0.86 ± 0.08
t_1/2 plasma (h)	1.66 ± 0.39	1.62 ± 0.69
t_1/2 brain (h)	1.25 ± 0.023	1.12 ± 0.01