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Pit-1 and Pit-2 mRNA expression by real-time RT-PCR after 24 hr incubation with DMSO (control) or insulin, with or without wortmannin or PD98059 (n=4). A. Insulin stimulated Pit-1 mRNA to 1.2-fold control (#p<0.01). This was inhibited by PD98059 (**p<0.01 vs. insulin) but not wortmannin. B. Insulin did not affect Pit-2 mRNA, but wortmannin and PD98059 each significantly decreased Pit-2 expression (*p<0.05 and **p<0.01 vs. insulin respectively).
