Table 1.

Cross-sectional and time-lagged associations of one disorder, either MDE or GAD, predicting the first onset of the other disorder as a function of time since onset of the primary disorder and cohort in the NCS-2 panel sample (n=5001)

			Cohorts (Age at baseline)
	Total		15–24		25–39		40–54
	OR	(95% CI)	OR	(95% CI)	OR	(95% CI)	OR	(95% CI)
I. Temporally primary MDE predicting subsequent GAD
Total	2.7*	(2.1–3.5)	3.7*	(2.6–5.2)	2.4*	(1.6–3.7)	1.7*	(1.0–2.9)
0 Years since onset of MDE	54.4*	(37.3–79.3)	51.9*	(36.1–74.5)	50.0*	(28.7–87.3)	40.7*	(12.1–137.4)
1–2 Years since onset of MDE	7.9*	(4.7–13.3)	9.3*	5.5–15.8	5.7*	(2.1–15.7)	4.7*	(2.0–10.8)
3–5 Years since onset of MDE	4.7*	(3.3–6.5)	6.6*	(3.7–11.5)	2.5*	(1.2–5.1)	2.4	(0.8–7.1)
6–10 Years since onset of MDE	2.8*	(1.8–4.3)	4.0*	(1.9–8.4)	2.3*	(1.3–3.9)	0.2	(0.0–1.2)
11+ Years since onset of MDE	3.5*	(2.4–5.0)	2.8*	(1.0–8.0)	4.1*	(2.5–6.5)	2.5*	(1.3–4.8)
II. Temporally primary GAD predicting subsequent MDE
Total	3.2*	(2.3–4.3)	3.6*	(2.2–6.0)	3.0*	(2.0–4.6)	3.1*	(1.7–5.6)
0 Years since onset of GAD	54.1*	(37.0–79.1)	51.9*	(35.9–74.9)	49.0*	(27.9–86.1)	42.2*	(12.0–148.1)
1–2 Years since onset of GAD	8.9*	(5.5–14.4)	7.5*	(3.5–16.2)	5.2*	(2.2–12.5)	23.0*	(7.7–68.7)
3–5 Years since onset of GAD	3.9*	(2.4–6.4)	4.3*	(2.2–8.2)	4.2*	(1.9–9.6)	0.4	(0.1–2.2)
6–10 Years since onset of GAD	2.0*	(1.2–3.3)	3.1*	(1.2–8.3)	1.8*	(1.0–3.4)	0.6	(0.1–3.3)
11+ Years since onset of GAD	2.8*	(1.9–4.2)	1.6	(0.4–6.3)	3.4*	(2.0–5.6)	3.0*	(1.4–6.7)

^*Significant at the .05 level, two-sided test

¹Based on a discrete-time survival model with person-year as the unit of analysis, controlling for cohort (age at interview), gender, race-ethnicity, and person-year.