Table 2.
Plasma amino acid concentrations and mood ratings prior to amino acid ingestion (T0), immediately prior to scanning (T5) and immediately after scanning (T7) in the rMDD patients and controls. Figures represent the mean (SD).
| Controls | rMDD patients | Statistical analysis | |||
|---|---|---|---|---|---|
| TRP+ | TRP- | TRP+ | TRP- | ||
| Tryptophan concentration (uM/l) | Treatment × time interaction: F(1,40)=214.1, p<0.001 | ||||
| T0 | 49.4 (15.9) | 50.8 (14.4) | 52.3 (9.7) | 55.0 (13.9) | |
| T5 | 91.7 (44.2) | 16.7 (11.2) | 105.4 (30.4) | 13.1 (5.6) | |
| T7 | 59.5 (23.0) | 21.8 (15.2) | 69.3 (29.9) | 16.2 (10.3) | |
| Tryptophan:ΣLNAA ratio | Treatment × time interaction: F(1,40)=50.7, p<0.001 | ||||
| T0 | 0.11 (0.06) | 0.11 (0.05) | 0.13 (0.05) | 0.13 (0.05) | |
| T5 | 0.07 (0.05) | 0.01 (0.01) | 0.08 (0.04) | 0.01 (0.01) | |
| T7 | 0.06 (0.04) | 0.02 (0.02) | 0.08 (0.04) | 0.02 (0.02) | |
| HAM-D | Main effect of group: F(1,41)=19.8, p<0.001 Main effect of time: F(2,82)=11.7, p<0.001 | ||||
| T0 | 0.6 (1.4) | 0.3 (0.7) | 1.2 (1.5) | 1.8 (1.7) | |
| T5 | 1.5 (2.0) | 1.5 (1.9) | 3.4 (3.8) | 2.4 (2.4) | |
| T7 | 1.0 (1.0) | 1.1 (1.5) | 3.5 (3.0) | 3.4 (3.6) | |
| HAM-A | Main effect of group: F(1,41)=16.6, p<0.001 Main effect of time: F(2,82)=8.0, p=0.001 | ||||
| T0 | 0.6 (0.9) | 0.7 (1.1) | 1.7 (1.8) | 2.1 (2.3) | |
| T5 | 1.5 (2.3) | 1.3 (1.8) | 2.6 (2.7) | 3.0 (3.5) | |
| T7 | 1.1 (1.3) | 1.3 (1.4) | 3.3 (2.9) | 4.0 (3.8) | |
| POMS tension | Main effect of group: F(1,40)=10.4, p=0.003 | ||||
| T0 | 2.2(2.3) | 1.8(1.6) | 3.1(3.1) | 4.5(4.5) | |
| T5 | 2.5(2.0) | 1.5(1.2) | 3.3(2.6) | 3.9(4.5) | |
| T7 | 1.6(1.8) | 1.9(1.3) | 4.1(5.2) | 5.0(5.4) | |
| POMS depression | Main effect of group: F(1,40)=6.0, p=0.018 Main effect of treatment: F(1,40)=4.8, p=0.034 | ||||
| T0 | 0.8(2.2) | 1.1(2.6) | 1.5(2.4) | 3.5(4.2) | |
| T5 | 0.3(0.7) | 0.4(1.2) | 0.9(1.9) | 1.7(4.1) | |
| T7 | 0.2(0.5) | 0.5(1.3) | 2.1(5.8) | 2.7(5.6) | |
| POMS anger | Main effect of group: F(1,40)=7.1, p=0.011 | ||||
| T0 | 0.6(1.1) | 0.8(1.9) | 1.0(1.4) | 2.3(3.5) | |
| T5 | 0.5(1.0) | 0.1(0.3) | 1.7(2.8) | 1.9(3.3) | |
| T7 | 0.5(1.1) | 0.3(0.8) | 1.5(3.4) | 2.8(6.8) | |
| POMS vigor | Main effect of group: F(1,40)=7.5, p=0.009 Main effect of time: F(2,80)=19.4, p<0.001 | ||||
| T0 | 19.6(6) | 19.6(5.8) | 16.8(7.4) | 14.6(7.4) | |
| T5 | 17.8(6) | 16.9(5.3) | 12.1(8.2) | 11.0(7.8) | |
| T7 | 17.5(6.6) | 17.1(5.9) | 13.4(8.9) | 9.9(9.2) | |
| POMS fatigue | Main effect of group: F(1,40)=6.2, p=0.017 Main effect of time: F(2,80)=8.9, p<0.001 | ||||
| T0 | 2.1(2.7) | 1.3(1.8) | 2.5(2.4) | 3.6(3.6) | |
| T5 | 3.3(4.4) | 2.6(3.1) | 5.0(5.4) | 5.3(5.9) | |
| T7 | 3.4(3.8) | 2.7(3.1) | 4.7(5.1) | 6.1(6.2) | |
| POMS confusion | Main effect of group: F(1,40)=12.1, p=0.001 | ||||
| T0 | 1.9(1.9) | 2.1(2.2) | 3.0(2.5) | 3.7(2.4) | |
| T5 | 2.4(1.4) | 2.4(1.7) | 3.9(2.4) | 4.3(3.4) | |
| T7 | 2.1(1.5) | 2.4(1.8) | 3.9(2.3) | 4.4(3.7) | |