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Expression of Hand2 in the early developing palatal shelf. (A–C) In the anterior palatal shelf, Hand2 is expressed in the epithelium including MEE and mesenchyme at E11.5 (A), E12.5 (B) and E13.5 (C). (D–F) In the posterior palatal shelf, Hand2 expression is not detectable at E11.5 (D) and E12.5 (E). However, at E13.5, Hand2 transcripts (arrows) are specifically detected in the epithelium of the lateral junction of the palatal shelf and mandible (F). T, tongue; PS, palatal shelf.
