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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Dev Biol. 2009 Mar 31;330(1):131–141. doi: 10.1016/j.ydbio.2009.03.021

Figure 5.

Figure 5

Down-regulation of Shh and its downstream genes in the palatal shelf of Hand2 hypomorphic mice. (A) Expression of Shh is detected in the MEE (black arrow) and the rugal epithelium (white arrow) of an E13.5 control palate. (B) Shh expression is significantly down-regulated in the MEE (black arrow), but remains unaffected in the rugal epithelium (white arrow) of an E13.5 Hand2LoxP/− embryo. (C, E) Expression of Ptc (C) and Bmp2 (E) in E13.5 control palatal shelves. (D) Ptc expression is down-regulated in the palatal shelf of an E13.5 Hand2LoxP/− embryo. Note specific gene down-regulation in the palatal mesenchyme adjacent to the MEE (arrow). (F) Bmp2 expression is reduced in the palatal shelf of an E13.5 Hand2LoxP/− embryo. Note the expression in the maxillary mesenchyme and the tongue is not affected. T, tongue