Table 3.

Post-seroconversion CD4 Cell Counts by Calendar Period during the Course of the HIV Epidemic. Unadjusted and Adjusted Linear Regression Models (n=2174)

	Unadjusted Model			Adjusted Modela
Factor	Estimate	Standard Error	P-value	Estimate	Standard Error	P-value
Seroconverting Period
1985-1990	Referent			Referent
1991-1995	-79.0	14.2	<0.0001	-65.0	14.2	<0.0001
1996-2001	-139.5	14.6	<0.0001	-106.9	20.1	<0.0001
2002-2007	-118.0	15.6	<0.0001	-101.5	20.7	<0.0001
Seroconverting Window
<1 year				56.3	21.0	0.007
1 - <2 years				35.7	20.7	0.08
2- <3 years				8.8	22.3	0.69
3-4 years				Referent
Time from HIV diagnosis to CD4 count
-30 to 29 days				63.5	44.5	0.15
30-89 days				49.3	44.1	0.26
90-149 days				12.4	47.8	0.80
150-182 days				Referent
Baseline Viral Load, copies/ml
Missing				133.0	22.6	<0.0001
≤1000				289.9	26.0	<0.0001
1001-4000				228.3	25.8	<0.0001
4001-10000				142.1	24.5	<0.0001
10001-50000				94.7	19.2	<0.0001
50001-100000				56.9	22.3	0.01
>100000				Referent
Age per 10 years				-20.5	7.8	0.008
Race
White/non-Hispanic				46.5	16.4	0.005
African American				6.8	16.4	0.68
Other				Referent
Gender, female				32.4	24.9	0.19
BMI Categoryb, kg/m2
Missing				-7.2	14.4	0.62
≤24.9				-19.5	14.7	0.18
25-29.9				Referent
≥30				-13.7	26.1	0.60

BMI, body mass index;

^aAdjusted for all variables in the table as well as site of enrollment

^bBMI categorized as <24.9 kg/m² as underweight or normal weight at HIV diagnosis, >30 kg/m² as obese, and 25-30 kg/m² as overweight