Table 3.

Treatment Outcomes

				NX versus PL		NX versus NX + Ser
	Placebo (n = 34)	NX (n = 34)	NX + SER (n = 33)	p-value	OR/HR/ES (LL/UL)	p-value	OR/HR/ES (LL/UL)
ITT sample
Primary outcomes
Total abstinence (n, %)	4(12)	12(35)	10 (30)	0.027	4.37 (1.19/16.11)a	0.634	1.30 (0.45/3.77)a
Relapse to a heavy	28 (82)	22 (65)	22 (67)	0.093	1.64 (0.92/2.90)b	0.874	0.95 (0.53/1.73)b
drinking day (n, %)
Secondary outcomes
Percent days abstinent     (Mean, SD)	85.7 (2.96)	94.8 (3.09)	96.3 (3.08)	0.024	0.53(0.03/1.02)c	0.710	0.09 (−0.40/0.58)c
Percent days heavy drinking     (Mean, SD)	11.2 (2.92)	3.7 (3.02)	3.0 (3.04)	0.059	0.44 (−0.05/0.93)c	0.859	0.04 (−0.45/0.53)c
Drinks per drinking day     (Mean, SD)	3.9 (0.82)	3.6 (0.85)	1.9 (0.85)	0.728	0.08 (−0.40/0.56)c	0.131	0.35 (−0.14/0.85)c
GGT change from baseline     (Mean, SD)	19.2 (13.46)	23.2 (13.39)	43.2(13.61)	0.964	0.05 (−0.44/0.55)c	0.427	0.26 (−0.23/0.76)c
DrInC (n, % reporting     any problems)	22 (76)	14(45)	14 (47)	0.020	0.264 (0.09/0.81)a	0.948	0.97 (0.35/2.68)a
Alcohol Urge Questionnaire     (Mean, SD)	12.8 (0.96)	12.3 (0.97)	13.5(1.03)	0.671	0.11 (−0.42/0.64)c	0.353	0.23 (−0.30/0.77)c
CES-Depression (Mean, SD)	10.1 (0.93)	10.9 (0.94)	9.8 (0.97)	0.520	0.16 (−0.37/0.69)c	0.383	0.22 (−0.32/0.76)c
	(n = 22)	(n = 24)	(n = 22)
Native subsample
Primary outcomes
Total abstinence (n, %)	4(18)	8(33)	8(36)	0.224	2.42 (0.58/10.11)a	0.880	0.91 (0.26/3.20)a
Relapse to a heavy drinking     day (n, %)	17(77)	16(67)	14 (64)	0.224	1.56 (0.76/3.20)b	0.972	0.99 (0.48/2.04)b
Secondary outcomes
Percent days abstinent	88.8 (3.03)	96.6 (2.90)	96.9 (3.02)	0.060	0.56 (−0.05/1.16)c	0.930	0.03 (−0.57/0.62)c
Percent days heavy drinking	8.5 (2.91)	2.8 (2.76)	0.6 (2.90)	0.142	0.43 (−0.17/1.03)c	0.578	0.16 (−0.43/0.75)c
Drinks per drinking day	4.2 (0.93)	4.0 (0.89)	1.9 (0.92)	0.830	0.06 (−0.53/0.65)c	0.095	0.50 (−0.10/1.10)c
GGT change from baseline	21.8(18.81)	17.2 (16.98)	61.0(18.52)	0.975	0.06 (−0.55/0.66)c	0.141	0.54 (−0.08/1.16)c
DrInC (n, % reporting any problems)	13(72)	8(38)	8(42)	0.026	0.20 (0.05/0.83)a	0.715	0.785 (0.21/2.88)a
Alcohol Urge Questionnaire	11.2 (1.25)	12.6(1.16)	13.4(1.33)	0.405	0.27 (−0.39/0.93)c	0.637	0.15 (−0.50/0.81)c
CES-Depression	10.2 (1.21)	11.8 (1.12)	10.2 (1.21)	0.295	0.34 (−0.32/0.99)c	0.310	0.33 (−0.32/0.98)c

OR, odds ratio; HR, hazard ratio; ES, effect size estimates are reported as Cohen’s d-values; LL/UL, lower limit/upper limit.

^aOR.

^bHR.

^cES.