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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Clin Cancer Res. 2009 Aug 25;15(17):5379–5388. doi: 10.1158/1078-0432.CCR-09-0265

Figure 4. Fractionated radiotherapy given to TSA tumor-bearing mice in 3 doses of 8 Gy is more effective than 5 doses of 6 Gy in synergizing with anti-CTLA-4 antibody.

Figure 4

(A) Tumor growth delay of primary irradiated tumors (left panel) and secondary non-irradiated tumor (right panel) in mice treated with PBS (closed circles), 8 Gy × 3 + 9H10 (open squares), or 6 Gy × 5 + 9H10 (open triangles). 9H10 was given on days 14, 17, and 20. Data are the mean ± SE of 5 mice/group. (B) Tumor weight of primary (C) and secondary (D) tumors at day 35. Data are the mean ± SE. The number of mice with complete tumor regression over the total number of mice per group is indicated.

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