Table 4.
Associations of positive anti-B2GPI and aCL antibody testing with clinical features of macrovascular disease and mortality in SSc patients
| Digital Loss | Cases (n=75) |
Controls (n=75) |
OR (95% CI)§ | OR (95%CI)¶ |
|---|---|---|---|---|
| Anti-B2GPI | ||||
| Any Positive % (n) | 36 (27) | 19 (14) | 2.4 (1.1, 5.3) | |
| IgM | 27 (20) | 15 (11) | 2.0 (0.9, 4.5) | |
| IgA | 17 (13) | 5 (4) | 4.0 (1.1, 14.2) | |
| IgG | 1 (1) | 0 (0) | NA | |
| Anti-cardiolipin | ||||
| Any positive % (n) | 24 (18) | 13 (10) | 2.1 (0.9, 5.3) | |
| IgM | 19 (14) | 12 (9) | 1.7 (0.7, 4.4) | |
| IgA | 4 (3) | 0 (0) | NA | |
| IgG | 9 (7) | 3 (2) | 6.0 (0.7, 49.8) | |
| Active Digital Ischemia | Active (n=52) |
Inactive (n=98) |
||
| Anti-B2GPI | ||||
| Any Positive % (n) | 50 (26) | 15 (15) | 5.5 (2.6, 12.0) | 9.4 (3.5, 25.4) |
| IgM | 38 (20) | 11 (11) | 4.9 (2.1, 11.4) | 13.9 (4.4, 43.5) |
| IgA | 23 (12) | 5 (5) | 5.6 (1.8, 16.9) | 4.5 (1.4, 15.3) |
| IgG | 0 (0) | 1 (1) | NA | NA |
| Anti-cardiolipin | ||||
| Any % (n) | 21 (11) | 17 (17) | 1.3 (0.5, 3.0) | 1.2 (0.5, 3.3) |
| IgM | 19 (10) | 13 (13) | 1.6 (0.6, 3.8) | 1.7 (0.6, 4.9) |
| IgA | 6 (3) | 0 (0) | NA | NA |
| IgG | 6 (3) | 6 (6) | 0.9 (0.2, 3.9) | 0.5 (0.1, 2.8) |
| eRVSP | >40mmHg (n=56) |
<40 mmHg (n=94) |
||
| Anti-B2GPI | ||||
| Any Positive % (n) | 48 (27) | 15 (14) | 5.3 (2.5, 11.5) | 4.8 (1.0, 11.4) |
| IgM | 38 (21) | 11 (10) | 5.0 (2.2, 11.8) | 5.4 (2.1, 14.4) |
| IgA | 21 (12) | 5 (5) | 4.9 (1.6, 14.6) | 4.6 (1.3, 15.7) |
| IgG | 2 (1) | 0 (0) | NA | NA |
| Anti-cardiolipin | ||||
| Any Positive % (n) | 27 (15) | 14 (13) | 2.3 (1.0, 5.2) | 1.7 (0.7, 4.1) |
| IgM | 21 (12) | 12 (11) | 2.1 (0.8, 5.0) | 1.6 (0.6, 4.2) |
| IgA | 5 (3) | 0 (0) | NA | NA |
| IgG | 13 (7) | 2 (2) | 6.6 (1.3, 32.9) | 4.1 (0.7, 22.4) |
| Status | Dead (n=39) |
Alive (n=98) |
||
| Anti-B2GPI | ||||
| Any Positive % (n) | 43 (17) | 23 (23) | 2.5 (1.1, 5.5) | 2.9 (1.1, 7.7) |
| IgM | 30 (12) | 18 (17) | 2.0 (0.86, 4.7) | 3.1 (1.1, 9.2) |
| IgA | 23 (9) | 7 (7) | 3.9 (1.3, 10.9) | 2.8 (0.8, 9.6) |
| IgG | 0 (0) | 1 (1) | NA | NA |
| Anti-cardiolipin | ||||
| Any % (n) | 25 (10) | 14 (14) | 2.0 (0.8, 5.0) | 2.2 (0.8, 6.3) |
| IgM | 23 (9) | 11 (11) | 2.3 (0.8, 6.0) | 2.8 (0.9, 8.6) |
| IgA | 8 (3) | 0 (0) | NA | NA |
| IgG | 8 (3) | 5 (5) | 1.5 (0.3, 6.5) | 1.1 (0.2, 6.8) |
§
Based on an unadjusted conditional logistic regression (for Digital Loss) or logistic regression models for Digital Ischemia, eRVSP and Mortality.
¶
Odds ratio with 95% confidence interval adjusted for age, gender, race, disease type, smoking and centromere status.