. Author manuscript; available in PMC: 2009 Sep 17.

Published in final edited form as: Biol Psychiatry. 2008 Feb 13;63(11):1066–1074. doi: 10.1016/j.biopsych.2007.12.002

Table 2.

Effects of prenatal cocaine treatment on the postnatal expression of homer 1.

Mean density values (mean±SEM) measured in different striatal regions on rostral, middle and caudal levels are given for mice that were prenatally exposed to saline (PSAL) or cocaine (PCOC) and tested at postnatal days (P) 15, P36 or P60 after an injection of saline (sal) or 15 mg/kg cocaine (coc). Responses to the cocaine challenge are also shown in percentage of values in respective saline controls (%). Striatum (S): m, medial; dl, dorsolateral; c, central; l, lateral; v, ventral; tot, total. Nucleus accumbens (NA): C, core; Sm, medial shell; Sl, lateral shell.

age	area	PSALsal	PCOCsal	PSALcoc	PCOCcoc	PSALcoc(%)	PCOCcoc(%)
P15	rostral
	S m	46.1±0.7	44.2±1.5	53.1±1.4^*	54.9±2.8^**	115.1±3.1	124.2±6.3
	S dl	46.1±1.4	45.9±1.2	49.1±1.5	51.0±2.2	106.5±3.2	111.0±4.8
	S tot	44.5±0.8	42.7±1.0	48.7±1.2	51.9±2.5^**	109.4±2.8	121.7±5.9
	NA C	35.7±1.8	32.7±1.8	36.4±2.4	39.6±2.4	101.8±6.8	120.9±7.4
	NA Sm	33.6±2.1	32.5±2.2	29.2±2.3	29.7±1.8	86.8±7.0	91.2±5.4
	NA Sl	35.0±2.1	37.7±2.5	35.3±2.1	32.8±2.5	100.8±6.1	86.9±6.5

	middle
	S m	43.1±0.9	40.6±1.1	53.1±1.8^***	53.8±2.3^***	123.0±4.3	132.5±5.8
	S c	45.4±0.6	44.8±1.2	52.7±1.6^*	53.1±2.6^**	116.1±3.5	118.5±5.7
	S l	50.7±0.9	50.8±1.7	55.7±1.6	52.7±2.2	109.7±3.2	103.8±4.2
	S v	27.3±1.2	29.7±1.9	30.5±1.8	30.4±1.3	111.7±6.6	102.4±4.3
	S tot	42.3±0.7	42.2±1.4	48.7±1.0^*	48.5±2.1^*	115.0±2.4	114.9±5.0

	caudal
	S tot	33.8±1.4	33.5±1.0	36.0±2.2	34.6±2.1	106.4±6.4	103.4±6.4

P36	rostral
	S m	47.7±1.3	47.9±1.3	56.9±1.2^***	59.5±1.1^***	119.2±2.4	124.3±2.3
	S dl	48.9±1.5	51.1±1.6	53.2±1.3	54.7±1.5	108.7±2.8	107.0±2.9
	S tot	47.4±1.2	47.0±1.2	53.0±1.0^**	55.4±1.2^***	111.9±2.1	117.8±2.5
	NA C	33.4±1.3	30.2±1.8	37.9±1.9	36.2±1.6^*	113.5±5.8	120.0±5.3
	NA Sm	33.8±1.5	31.4±1.7	35.4±2.2	33.0±1.8	104.7±6.4	105.0±5.7
	NA Sl	30.8±3.3	35.7±1.8	38.9±2.1^*	40.1±1.4	126.2±6.7	112.1±3.8

	middle
	S m	49.6±1.7	47.2±1.4	59.7±1.1^***	63.0±1.8^***	120.2±2.2	133.3±3.8^##
	S c	46.4±1.9	45.9±1.6	51.0±1.7	52.5±1.3^*	110.0±3.7	114.3±2.9
	S l	50.2±2.2	51.9±2.0	58.9±2.2^*	58.2±1.9^*	117.3±4.3	112.0±3.7
	S v	29.9±2.3	31.5±2.0	31.2±0.7	30.9±0.6	104.3±2.3	98.1±1.9
	S tot	45.6±1.8	45.4±1.7	52.5±1.5^**	53.1±1.2^**	115.1±3.2	117.0±2.6

	caudal
	S tot	35.9±1.8	34.7±1.6	38.0±1.5	40.3±1.1	105.8±4.3	115.9±3.3

P60	rostral
	S m	51.4±0.9	51.8±1.3	59.8±0.8^***	62.3±0.5^***	116.3±1.5	120.2±1.1
	S dl	50.9±2.6	51.5±2.4	54.4±1.9	57.3±1.7	106.9±3.7	111.2±3.3
	S tot	50.5±1.1	50.5±1.1	54.6±0.7^**	57.4±0.6^*** ^#	108.2±1.5	113.6±1.3^#
	NA C	41.2±2.6	43.3±3.6	41.4±1.4	43.3±1.8	100.4±3.4	100.0±4.3
	NA Sm	41.2±1.9	41.5±2.3	40.1±1.3	39.6±2.0	97.3±3.0	95.4±4.9
	NA Sl	39.9±2.5	43.5±1.8	43.1±1.8	43.3±2.4	107.9±4.5	99.5±5.6

	middle
	S m	52.3±2.0	50.4±2.7	64.6±1.8^***	66.6±1.8^***	123.6±3.4	132.2±3.5
	S c	44.8±1.5	44.4±1.9	49.2±1.3	51.1±1.8^*	109.9±2.8	115.2±4.0
	S l	49.7±2.1	48.3±1.8	57.1±2.2^*	62.9±2.8^**	114.8±4.5	130.1±5.9
	S v	29.9±2.4	35.3±1.6	30.9±1.9	37.5±1.3^#	103.2±6.4	106.2±3.7
	S tot	45.5±1.4	45.6±1.7	50.9±1.0^*	54.7±1.3^***	111.8±2.2	120.0±2.9^#

	caudal
	S tot	36.8±1.5	37.1±1.6	41.3±0.5	42.3±1.6^*	112.3±1.4	114.0±4.2

^***

P < 0.001,

^**

p < 0.01,

p < 0.05, vs. respective saline control;

^##

p < 0.01,

p < 0.05, vs. PSALcoc.