Table 1.
Pfmdr-1 SNP profile of 160 P. falciparum isolates from Malawi
|
pfmdr-1 codon |
||||||
|---|---|---|---|---|---|---|
| 86 | 184 | 1034 | 1042 | 1246 | n | Prevalence (%) |
| N | Y | S | N | D | 106 | 66.3 (58.4 — 73.5) |
| Y | F | S | N | D | 20 | 12.5 (7.8 — 18.8) |
| N/Y | Y | S | N | D | 9 | 5.6 (2.6 — 10.4) |
| N/Y | Y/F | S | N | D | 6 | 3.8 (1.4 — 8.0) |
| N | Y/F | S | N | D | 4 | 2.5 (0.7 — 6.3) |
| N/Y | F | S | N | D | 3 | 1.9 (0.4 — 5.4) |
| Y | Y/F | S | N | D | 2 | 1.3 (0.2 — 4.4) |
| N | F | S | N | D | 2 | 1.3 (0.2 — 4.4) |
| Y | Y | S | N | D | 1 | 0.6 (0 — 3.4) |
| N | Y | S | N | Y | 1 | 0.6 (0 — 3.4) |
| N | Y | C | N | D | 1 | 0.6 (0 — 3.4) |
| N | Y | C | N | Y | 1 | 0.6 (0 — 3.4) |
| N/Y | Y/F | S | N | Y | 1 | 0.6 (0 — 3.4) |
| N | Y | S/C | N | D/Y | 1 | 0.6 (0 — 3.4) |
| N/Y | Y/F | S/C | N | D/Y | 1 | 0.6 (0 — 3.4) |
| N | Y | S | N | D/Y | 1 | 0.6 (0 — 3.4) |
Letters are abbreviations for different amino acids in the pfmdr-1 gene product. n = number of isolates with the listed set of alleles. Prevalence in parenthesis represents binomial exact 95% confidence intervals for the measured prevalence. Mutant alleles are indicated in bold; if both the wild type and mutant alleles were found in the same isolate, the genotype carried by the isolate was considered ‘mixed,’ for example, N/Y means the isolate carried both the wild type asparagine (N) residue and the mutant tyrosine (Y) residue at codon 86.