Table 3.

Left Ventricular Echocardiographic Z-Scores in 350 Children with and without Anti-heart failure and ACE Inhibition Therapy at Diagnosis of Cardiomyopathy (1990-1995)

Echocardiographic Z-score*	Therapy Mean (SD)	No Therapy Mean (SD)	P
Anti-heart failure Therapy
End-diastolic dimension	4.88 (2.52)	2.66 (2.91)	<0.001
End-systolic dimension	6.80 (2.50)	3.69 (3.43)	<0.001
Fractional shortening	-9.49 (2.96)	-5.71 (4.70)	<0.001
End-diastolic posterior wall thickness	-0.35 (2.49)	-0.82 (1.51)	0.16
End-diastolic septal wall thickness	-0.72 (2.11)	-1.19 (1.19)	0.11
ACE Inhibitor Therapy
End-diastolic dimension	5.06 (2.56)	3.48 (2.73)	<0.001
End-systolic dimension	6.92 (2.53)	5.17 (3.26)	<0.001
Fractional shortening	-9.38 (3.00)	-7.80 (4.35)	0.002
End-diastolic posterior wall thickness	-0.23 (2.55)	-0.93 (1.81)	0.028
End-diastolic septal wall thickness	-0.66 (2.13)	-1.14 (1.70)	0.13

^*Echocardiographic Z-scores are corrected for body surface area (end-diastolic and end-systolic dimension, and end-diastolic posterior and septal wall thickness and left ventricular mass) or corrected for age (fractional shortening). All mean Z-scores significantly differ (P<0.05) from normal (Z=0) except for end-diastolic posterior wall thickness in the therapy group.