TABLE 5.
Mutation rates in exo1 and rad27-pX8 mutants
| Mutation rate (×10−7 events/cell/generation) ± SDa
|
||
|---|---|---|
| Strain | Empty vectorb | POL30b |
| RAD27 | 2.8 ± 0.7 (1) | 5.8 ± 3 (1) |
| exo1Δ | 12 ± 3 (4) | 11 ± 1 (2) |
| rad27-pX8 | 53 ± 7 (19) | 12 ± 3 (2) |
| exo1Δ rad27-pX8 | 289 ± 59 (103) | 99 ± 26 (17) |
Mutation to canavanine resistance for cells grown in omission media is shown.
a
SD, standard deviation.
b
Values normalized to the RAD27 rates for empty vector (pRS424) or for POL30, as appropriate, are shown in parentheses. The pRS424.POL30 rate is significantly lower (P < 0.05) than the empty vector rate for the rad27-pX8 and the exo1Δ rad27-pX8 mutants.