TABLE 1.

Putative K. lactis orthologs or homologs of the S. cerevisiae Aft1/Aft2 iron-regulated genes

S. cerevisiae gene	ORF	Function	K. lactis gene	% identity/% similarity
FET3	YMR058W	Multicopper oxidase	KLLA0F26400gS	66/82
FTR1	YER145C	High-affinity iron permease	KLLA0A03025g	68/85
CCC2	YDR270W	Copper transport into vesicles	KLLA0F07447g	52/71
ATX1	YNL259C	Copper chaperone	KLLA0C02673gS	71/82
FIT1	YDR534C	Cell wall proteins	KLLA0C04994g	36/56
FIT2	YOR382W		KLLA0C05016g	57/71
FIT3	YOR383C		KLLA0A04323g	53/72
FET4	YMR319C	Low-affinity iron permease	KLLA0E14564g	55/70
CTH1	YDR151C	mRNA degradation	KLLA0D16610gS	43/59
CTH2	YLR136C			49/64
HMX1	YLR205C	Heme oxygenase	KLLA0D12474gS	61/78
FET5	YFL041W	Vacuolar multicopper oxidase	KLLA0D05489gS	60/77
FTH1	YBR207W	Vacuolar permease	KLLA0F28039g	66/79
SMF3a	YLR034C	Vacuolar iron transporter	KLLA0F17391gS	73/85
MRS3	YJL133W	Mitochondrial iron transport	KLLA0E15532gS	71/85
MRS4a	YKR052C			71/86
ARN1	YHL040C	Siderophore transporters	KLLA0A10439g	51–64/71–80
ARN2/TAF1	YHL047C		KLLA0E14652g
ARN3/SIT1	YEL065W		KLLA0C19272g
ARN4/ENB1	YOL158C		KLLA0C00220g
FRE1	YLR214W	Metalloreductases	KLLA0F04950g	28–44/51–63
FRE2	YKL220C		KLLA0E14542g
FRE3	YOR381W		KLLA0E05852g
FRE4	YNR060W		KLLA0F00616g
FRE5	YOR384W		KLLA0C04906g
FRE6	YLL051C

The first three columns contain the S. cerevisiae gene names, ORF names, and the associated protein functions according to the S. cerevisiae Genome Database. When possible, for each of the S. cerevisiae genes, a putative ortholog in the K. lactis genome is inferred (see materials and methods and File S1). If the putative ortholog is syntenic with the S. cerevisiae gene, there is a superscript s at the end of the K. lactis gene name. For each S. cerevisiae/K. lactis gene pair, the identity and similarity between the two genes are indicated. They were computed with the high scoring pairs of BLASTP, gaps excluded. Paralog pairs are indicated one above the other and underlined.

^aAft2-specific target genes (Courel et al. 2005).