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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Pain. 2009 Aug 5;145(3):341–349. doi: 10.1016/j.pain.2009.06.037

Figure 5.

Figure 5

Effects of peripheral administration of substance-P, IL-6 and NGF on mechanical sensetivity. A: Intra-plantar substance P and vehicle were given after baseline mechanical paw withdrawal threshold determination. B–C: Intra-plantar IL-6, NGF and vehicle given after baseline measurements of paw withdrawal threshed. Data of the effect of different doses of SP, IL-6 and NGF are presented as mean percent effect, with baseline values as being zero effect. Higher doses of NGF produced ongoing mechanical hyperalgesia for several days (Data not shown). D–E: Comparison of the paw withdrawal thresholds of wild type and ppt-A(−/−) mice at various time points given 1ng/15 µL of IL-6 and 50ng/15 µL of NGF by intra-plantar injection. Data are presented as Mean ± S.E.M and were analyzed by two way ANOVA with post hoc Bonferroni tests comparing strains at corresponding time points. *p<0.05, **p<0.01, ***p<0.001.