Table 3.
Antimicrobial compounds having significantly lower MICs in hop-resistant isolatesa.
| Antimicrobial compound | Median and Distribution of MIC (μg/ml) | p-valueb | |
|---|---|---|---|
| Hop-resistant | Hop-sensitive | ||
| Ampicillin | 0.25 (0.12-4) | 1 (0.12-4) | < 0.05 |
| Ciprofloxacin | 2 (0.5-NRc) | 4 (0.5-NR) | < 0.05 |
| Gatifloxacin | 1 (0.5-8) | 4 (1-NR) | < 0.05 |
| Penicillin | 0.12 (0.06-NR) | 2 (0.06-NR) | < 0.02 |
| Rifampin | 0.5 (0.5-2) | 1 (0.5-NR) | < 0.05 |
a Hop-resistance is as determined by the hop-gradient agar plate with ethanol method.
b p-value corresponds to U-test statistic as derived from the non-parametric Mann-Whitney U-test which is designed to examine whether two samples of observations came from the same distribution.
c NR; MIC not reached, isolate could grow at highest concentration of antibiotic tested.