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. Author manuscript; available in PMC: 2009 Sep 17.
Published in final edited form as: ACS Chem Biol. 2008 Aug 15;3(8):499–511. doi: 10.1021/cb800066p

Figure 3.

Figure 3

Pathway engineered synthesis scheme for: (a) ATP and (b) GTP. Reagents are color coded as: Stoichiometric isotopically labeled reagents (black), Phosphate and oxidizing equivalents as the driving force (red), and Recycled cofactors (blue). Cofactors are added in catalytic amounts, and intermediates that are generated in situ are shown in parentheses.